12. May prevent alzheimer’s disease
Ginger contains several bioactive chemicals that contribute to its recognized biological properties, including 6-gingerol, 6-shogaol, 10-gingerol, gingerdiones, gingerdiols, paradols, 6-dehydrogingerols, 5-acetoxy-6-gingerol, 3,5-diacetoxy-6-gingerdiol, and 12-gingerol. The main active chemicals are 6-shogaol and 6-gingerol. Scientific data supports ginger’s therapeutic characteristics, which include antioxidant and anti-inflammatory properties; nevertheless, a specific and less investigated bioactivity is the potential neuroprotective benefit. The rise in life expectancy has increased the prevalence of neurodegenerative diseases (NDs), which share neuropathological characteristics such as increased oxidative stress, neuroinflammation, and protein misfolding. Ginger phytochemical structure-activity correlations indicate that ginger may be a potential for treating NDs by targeting distinct ligand sites. Its bioactive components have the potential to alleviate neurological symptoms and pathological diseases by altering cell death or cell survival signaling molecules. Ginger’s cognitive-enhancing benefits could be explained in part by changes in both the monoamine and cholinergic systems in diverse brain locations. Furthermore, ginger inhibits the formation of inflammatory factors. The purpose of this review is to outline the benefits of ginger on the prevention of major neurodegenerative illnesses like Alzheimer’s, Parkinson’s, and multiple sclerosis. In Western countries, the number of persons over the age of 65 has steadily increased, increasing the risk of age-related neurological disorders. Alzheimer’s disease is the most common pathology, affecting about 26 million individuals globally today. By 2050, this figure is predicted to triple. There are no effective treatments for aging-related neurodegenerative illnesses, which tend to proceed irreversibly and have high personal and socioeconomic costs. The primary problems of scientific research are the prevention of these illnesses and the discovery of novel nutraceuticals and medications to counteract them. Plant-derived products have been shown to have anti-inflammatory and antioxidant properties, which have been linked to improvements in cognitive impairment. Neurodegenerative disorders are defined by neuroinflammation, oxidative stress, and protein misfolding, which results in brain damage, synaptic dysfunction, and neuronal apoptosis (13). In Alzheimer’s disease, oxidative stress is primarily caused by mitochondrial dysfunction, the intracellular accumulation of hyperphosphorylated tau () proteins in the form of neurofibrillary tangles, the excessive accumulation of beta-amyloid (A) extracellular plaques, and environmental and genetic factors. Antioxidant, anti-amyloidogenic, anti-inflammatory, and anti-cholinesterase effects have been demonstrated by gingerols.
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