{"id":3090,"date":"2021-10-13T04:27:43","date_gmt":"2021-10-13T04:27:43","guid":{"rendered":"https:\/\/healthnewscentral.com\/?p=3090"},"modified":"2021-10-13T04:27:43","modified_gmt":"2021-10-13T04:27:43","slug":"experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients","status":"publish","type":"post","link":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/","title":{"rendered":"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients"},"content":{"rendered":"
\"\"
Brandrator<\/figcaption><\/figure>\n

CRISPR gene-editing, also known as Cas9, is short for Clustered Regularly Interspaced Short Palindromic Repeats\/CRISPR associated protein 9. It is described by The Conversation<\/a> as an \u2018easier, cheaper and more efficient than previous strategies for modifying DNA.\u2019<\/p>\n

Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.<\/p>\n

For 55-year old patient, Carlene Knight, because of CRISPR, she has been able to circumnavigate her call center office without needing her walking stick, as well as see more colors vividly, and locate objects easier too.<\/p>\n

Meanwhile, another patient, 43-year old Michael Kalberer, also found that during his cousin\u2019s wedding, he could see more colors while on the dancefloor, as well as getting back some of his peripheral vision.<\/p>\n

Carlene and Michael were only two of seven patients that were given CRISPR that was directly injected into their eye, which was a procedural method that had never been done with CRISPR before. This normally entails \u2018removing cells, editing them in vitro<\/em>, and injecting them back where they were found.\u2019<\/p>\n

Although both of these patients, who suffer from a rare mutation in the retina called Leber congenital amaurosis<\/a> or LCA, are still far from being cured of their disease. But they are no longer considered legally blind. And although their treatment hasn\u2019t been successful for some patients within their three and nine-month follow up checkups, there were no negative side effects that were reported either.<\/p>\n

As for Ms. Knight, she shared, \u201cI\u2019ve always loved colors,\u201d as she lives near Portland. She went on to say, \u201cSince I was a kid it\u2019s one of those things I could enjoy with just a small amount of vision. But now I realize how much brighter they were as a kid because I can see them a lot more brilliantly now; it\u2019s just amazing.\u201d<\/p>\n

According to a report in NPR<\/a>, professor of ophthalmology, Mark Pennesi, who also has an MD and a Ph.D. from the Baylor College of Medicine<\/em>, he called the results \u201ca really amazing technology and very powerful,\u201d during a recent symposium.<\/p>\n

But like most other scientists and medical professionals, he also says that they should err on the side of caution, since there still need to be many more follow-up research requirements to be done before they can fully understand the value of the CRISPR trial on patients.<\/p>\n

Of course, early success stories of cases like Knight\u2019s and Kalberer\u2019s were so clear and substantial that it has caused researchers to move on to their next group of patients to see if they will also garner positive results.<\/p>\n

How CRSIPR works is by taking harmless viruses that have been taught to carry edited genes and injecting them into the retina where the cells cannot be taken out, which is considered the in vitro<\/em> approach. To make sure that the patients didn\u2019t lose their already limited vision fully, the very experimental treatment was only done to one eye of each patient, while the injection doses were also varied.<\/p>\n

For some patients, they didn\u2019t regain any of their vision, which could be due to the injection dose or because it was limited to just one retina. Dr. Pennesi chooses to believe that some of the patients that received the experimental treatment could have improved vision even nine months after they received the treatment, after the brain starts to eventually figure out how to manage any of the extra images.<\/p>\n

The treatment CRISPR has been used to treat other medical health issues such as sickle-cell disease<\/a>, hypertrophic cardiomyopathy<\/a>, and even to create an antidote<\/a> to the deadly Australian box jellyfish sting. If the CRISPR shows that it\u2019s safe to apply in vivo, then it could be huge in terms of helping \u2018genetic disorders inherent to organs that are difficult to draw samples from, such as the brain.\u2019<\/p>\n

Professor of ophthalmology at Harvard Medical School, Dr. Eric Pierce, who been assisting with the trails says, \u201cWe\u2019re thrilled to see early signs of efficacy because that means gene editing is working. This is the first time we\u2019re having evidence that gene editing is functioning inside somebody and it\u2019s improving \u2013 in this case \u2013 their visual function.\u201d<\/strong><\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

CRISPR gene-editing, also known as Cas9, is short for Clustered Regularly Interspaced Short Palindromic Repeats\/CRISPR associated protein 9. It is described by The Conversation as an \u2018easier, cheaper and more efficient than previous strategies for modifying DNA.\u2019 Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare […]<\/p>\n","protected":false},"author":9,"featured_media":3091,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[4],"tags":[957,777,956,76,959,16,958,779],"yoast_head":"\nExperiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients<\/title>\n<meta name=\"description\" content=\"Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients\" \/>\n<meta property=\"og:description\" content=\"Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"Health News Central\" \/>\n<meta property=\"article:published_time\" content=\"2021-10-13T04:27:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/healthnewscentral.com\/wp-content\/uploads\/2021\/10\/crispr.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"730\" \/>\n\t<meta property=\"og:image:height\" content=\"410\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"katcruz\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"katcruz\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\"},\"author\":{\"name\":\"katcruz\",\"@id\":\"https:\/\/healthnewscentral.com\/#\/schema\/person\/38b633af813eb345a6ed540cc63d452f\"},\"headline\":\"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients\",\"datePublished\":\"2021-10-13T04:27:43+00:00\",\"dateModified\":\"2021-10-13T04:27:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\"},\"wordCount\":730,\"publisher\":{\"@id\":\"https:\/\/healthnewscentral.com\/#organization\"},\"keywords\":[\"blind\",\"blindness\",\"CRISPR\",\"cure\",\"gene-editing\",\"health\",\"patients\",\"vision\"],\"articleSection\":[\"Health\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\",\"url\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\",\"name\":\"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients\",\"isPartOf\":{\"@id\":\"https:\/\/healthnewscentral.com\/#website\"},\"datePublished\":\"2021-10-13T04:27:43+00:00\",\"dateModified\":\"2021-10-13T04:27:43+00:00\",\"description\":\"Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.\",\"breadcrumb\":{\"@id\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/healthnewscentral.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/healthnewscentral.com\/#website\",\"url\":\"https:\/\/healthnewscentral.com\/\",\"name\":\"Health News Central\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/healthnewscentral.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/healthnewscentral.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/healthnewscentral.com\/#organization\",\"name\":\"Health News Central\",\"url\":\"https:\/\/healthnewscentral.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/healthnewscentral.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/healthnewscentral.com\/wp-content\/uploads\/2020\/03\/Screen-Shot-2020-03-06-at-6.14.51-AM.png\",\"contentUrl\":\"https:\/\/healthnewscentral.com\/wp-content\/uploads\/2020\/03\/Screen-Shot-2020-03-06-at-6.14.51-AM.png\",\"width\":1396,\"height\":484,\"caption\":\"Health News Central\"},\"image\":{\"@id\":\"https:\/\/healthnewscentral.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/healthnewscentral.com\/#\/schema\/person\/38b633af813eb345a6ed540cc63d452f\",\"name\":\"katcruz\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/healthnewscentral.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/85d53048a5155d19ec8889113281bc78?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/85d53048a5155d19ec8889113281bc78?s=96&d=mm&r=g\",\"caption\":\"katcruz\"},\"url\":\"https:\/\/healthnewscentral.com\/author\/katcruz\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients","description":"Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/","og_locale":"en_US","og_type":"article","og_title":"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients","og_description":"Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.","og_url":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/","og_site_name":"Health News Central","article_published_time":"2021-10-13T04:27:43+00:00","og_image":[{"width":730,"height":410,"url":"https:\/\/healthnewscentral.com\/wp-content\/uploads\/2021\/10\/crispr.jpg","type":"image\/jpeg"}],"author":"katcruz","twitter_card":"summary_large_image","twitter_misc":{"Written by":"katcruz","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/#article","isPartOf":{"@id":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/"},"author":{"name":"katcruz","@id":"https:\/\/healthnewscentral.com\/#\/schema\/person\/38b633af813eb345a6ed540cc63d452f"},"headline":"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients","datePublished":"2021-10-13T04:27:43+00:00","dateModified":"2021-10-13T04:27:43+00:00","mainEntityOfPage":{"@id":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/"},"wordCount":730,"publisher":{"@id":"https:\/\/healthnewscentral.com\/#organization"},"keywords":["blind","blindness","CRISPR","cure","gene-editing","health","patients","vision"],"articleSection":["Health"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/","url":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/","name":"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients","isPartOf":{"@id":"https:\/\/healthnewscentral.com\/#website"},"datePublished":"2021-10-13T04:27:43+00:00","dateModified":"2021-10-13T04:27:43+00:00","description":"Recently, this ground-breaking therapy was also used to partly help restore vision in patients suffering from a rare genetic disorder.","breadcrumb":{"@id":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/healthnewscentral.com\/experiment-with-crispr-gene-editing-proves-successful-by-restoring-vision-in-legally-blind-patients\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/healthnewscentral.com\/"},{"@type":"ListItem","position":2,"name":"Experiment With CRISPR Gene-Editing Proves Successful By Restoring Vision In Legally Blind Patients"}]},{"@type":"WebSite","@id":"https:\/\/healthnewscentral.com\/#website","url":"https:\/\/healthnewscentral.com\/","name":"Health News Central","description":"","publisher":{"@id":"https:\/\/healthnewscentral.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/healthnewscentral.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/healthnewscentral.com\/#organization","name":"Health News Central","url":"https:\/\/healthnewscentral.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/healthnewscentral.com\/#\/schema\/logo\/image\/","url":"https:\/\/healthnewscentral.com\/wp-content\/uploads\/2020\/03\/Screen-Shot-2020-03-06-at-6.14.51-AM.png","contentUrl":"https:\/\/healthnewscentral.com\/wp-content\/uploads\/2020\/03\/Screen-Shot-2020-03-06-at-6.14.51-AM.png","width":1396,"height":484,"caption":"Health News Central"},"image":{"@id":"https:\/\/healthnewscentral.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/healthnewscentral.com\/#\/schema\/person\/38b633af813eb345a6ed540cc63d452f","name":"katcruz","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/healthnewscentral.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/85d53048a5155d19ec8889113281bc78?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/85d53048a5155d19ec8889113281bc78?s=96&d=mm&r=g","caption":"katcruz"},"url":"https:\/\/healthnewscentral.com\/author\/katcruz\/"}]}},"_links":{"self":[{"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/posts\/3090"}],"collection":[{"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/comments?post=3090"}],"version-history":[{"count":0,"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/posts\/3090\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/media\/3091"}],"wp:attachment":[{"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/media?parent=3090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/categories?post=3090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthnewscentral.com\/wp-json\/wp\/v2\/tags?post=3090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}